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Drugs That Should Be Avoided For G6PD Deficient

Analgesics / Antipyretics:

  • Anacin
  • Aspirin
  • Paracetamol (acetaminophen)
  • Bufferin
  • Dipirona
  • Ecotrin
  • Empirin
  • Excedrin
  • Pepto Bismol
  • Phenacetin (acetophenetidin)
  • Probenecid

 

Antihistamine:

  • Azatadine
  • Brofeniramine
  • Dexchlorphyrramine
  • Diphenhydramine
  • Hydroxyzine
  • Loratadine
  • Cetirizine

Antimalarials:

  • Chloroquine (Aralen)
  • Mefloquine (Lariam)
  • Pamaquine
  • Pentaquine
  • Primaquine
  • Quinidine
  • Quinine

Sulfonamides and Sulfones:

  • Dapsone
  • Furosemide (Lasix)
  • Sulfacetamide (Sulamyd)
  • Sulfamethoxazole (Bactrim, Septra)
  • Sulfanilamide
  • Sulfasalazine (Azulfidine)
  • Sulfisoxazole (Gantrisin)
  • Sulfamethoxypyridazine

Cytotoxic / Antibacterial:

  • Nalidixic Acid
  • Para-Aminosalicylic Acid
  • Chloramphenicol
  • Co-Trimoxazole
  • Furazolidone
  • Furmetonol
  • Neoarsphenamine
  • Streptomycin

Nitrofurans:

  • Nitrofurantoin (Furadantin, Macrobid, Macrodantin)
  • Nitrofurazone (Furacin)

Quinolones and Fluoroquinolones:

  • Ciprofloxacin (Cipro)
  • Levofloxacin (Levaquin)
  • Moxifloxacin (Avelox, Vigamox)
  • Norfloxacin (Noroxin)

Cardiovascular Drugs:

  • Captopril
  • Hydralazine
  • Procainamide
  • Quinidine
  • Enalapril

MISCELLANEOUS:

  • Acetylsalicylic Acid (ASA, Mejoral)
  • Ascorbic Acid (Vitamin C)
  • Para-Aminobenzoic Acid (Complex B10)
  • Tonic water
  • Alpha Methyldopa
  • Aminopyrine
  • Antazoline
  • Methylene Blue (used in contrast)
  • Toluidine blue (used in contrast)
  • Bupivacaine (anesthesia)
  • Colchicine
  • Artificial Dyes
  • Diphenhydramine (Anador, Caladryl)
  • Dimercaprol
  • Fava beans
  • Phenylbutazone
  • Phenytoin (Hydantal)
  • Glibenclamide
  • Isoniazid
  • L-Dopa
  • Mestranol
  • Naphthalene
  • Niridazole
  • Piridium
  • Pyrimethamine
  • Sulfacillin
  • Sulfadiazine
  • Sulfaguanidine
  • Sulfamerazine
  • Sulfamethoxypyridazine
  • Trimetropim (Bactrim)
  • Trinitrotoluene
  • Tripelenamine
  • Urato Oxidase
  • Red wine
  • Vitamin K (Kanakion)
  • Acetylphenylhydrazine
  • Beta-Naphthol
  • Chloramphenicol
  • Dimercaprol
  • Glyburide (Diabeta)
  • Henna
  • Menthol
  • Penicillamine
  • Phenazopyridine
  • Phenylhydrazine
  • Rasburicase (Elitek)
  • Tolbutamide (Orinase)

SOURCE:

PEDIATRIC HEMATOLOGY DEPARTMENT OF THE SCHOOL PAULISTA DE MEDICINA. RESEARCHERS DR.SERGIO AUGUSTO PERLAMAGNA (CRM: 99243), DRA ELISA COUTO PERES RIBEIRO (CRM: 125075)

Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371(9606):64–74

Minucci A, Moradkhani K, Hwang MJ, et al. Glucose-6-phosphate dehydrogenase (G6PD) mutations database: review of the ‘old’ and update of the new mutations. Blood Cells Mol Dis. 2012;48(3):154–165.

The Association is affiliated with UNIAMO, Italian Federation for Rare Diseases, which is member of EURORDIS, European Organization for Rare Diseases.

 

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LISTA DE MEDICAMENTOS QUE DEVEM SER EVITADOS EM PACIENTES COM DEFICIÊNCIA G6PD

ANALGÉSICOS/ANTIPIRÉTICOS CITOTÓXICOS/ANTIBACTERIANOS MISCELÂNIAS
Acetanilida Ácido Nalidixico (Wintomylon) Ácido Acetilsalicilico (AAS, Melhoral)
Acetofenetidina Ácido Para-Aminosalicilico Ácido Ascórbico (Vitamina C)
Acetominofen (Paracetamol) Ciprofloxacina
Amidopirina Cloranfenicol Ácido Para-Aminobenzóico (Complexo B10)
Antipirina Co-Trimoxazol Água Tônica
Aspirina Furazolidona Alfa Metildopa
Dipirona Furmetonol Aminopirina
Fenacetina Levofloxacina Antazolina
Piramidona Neoarsfenamina Azul de Metileno (usado em contraste)
Probenicida Nitrofurantoìna Azul de Toluidina (usado em contraste)
Nitrofurazona Bupivacaina (anestesia)
ANTIMALÁRICOS Noriloxacina Colchicina
Cloroquina Corantes Artificiais
Hidroxicloroquina SULFONAMIDAS/ SULFONAS Difenidramina (Anador,  Caladryl)
Mepacrina Dapsona Dimercaprol
Pamaquina Sulfacetamida Estreptomicina
Pentaquina Sulfametoxipirimidina Feijão de Fava
Primaquina Sulfanilamida Fenilbutazona
Quinina Sulfapiridina Fenitoina (Hidantal)
Quinocida Sulfasalazina Glibenclamida
Sulfisoxazole Isoniazida
ANTI-HISTAMINICO L-Dopa
Azatadina (Cedrin) DROGAS CARDIOVACULARES Mestranol
Bronfeniramina (Decongex Plus) Captopril Naftaleno
Cetirizina (Zyrtec) Enalapril Niridazol
Dexclorfeniramina (Polaramine) Hidralazina Piridium
Difenidramina(Anador,Notuss,Caladryl) Procainamida Pirimetamina
Hidroxina (Hixizine) Quinidina Probenicid
Loratadina (Claritin) Sulfacitina
Sulfadiazina
Sulfaguanidina
Sulfamerazina
Sulfametoxipiridazina
Trimetropim (Bactrim)
Trinitrotolueno
Tripelenamine
Urato Oxidase
Vinho Tinto
Vitamina K (Kanakion)

FONTE: DEPARTAMENTO DE HEMATOLOGIA PEDIÁTRICA DA ESCOLA PAULISTA DE MEDICINA.

COLABORADORES PARTICIPANTES DO PROJETO MCQ-G6PD: DR.SERGIO AUGUSTO PERLAMAGNA (CRM: 99243), DRA ELISA COUTO PERES RIBEIRO (CRM: 125075)

 

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