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Drugs That Should Be Avoided For G6PD Deficient

Analgesics / Antipyretics:

  • Anacin
  • Aspirin
  • Paracetamol (acetaminophen)
  • Bufferin
  • Dipirona
  • Ecotrin
  • Empirin
  • Excedrin
  • Pepto Bismol
  • Phenacetin (acetophenetidin)
  • Probenecid

 

Antihistamine:

  • Azatadine
  • Brofeniramine
  • Dexchlorphyrramine
  • Diphenhydramine
  • Hydroxyzine
  • Loratadine
  • Cetirizine

Antimalarials:

  • Chloroquine (Aralen)
  • Mefloquine (Lariam)
  • Pamaquine
  • Pentaquine
  • Primaquine
  • Quinidine
  • Quinine

Sulfonamides and Sulfones:

  • Dapsone
  • Furosemide (Lasix)
  • Sulfacetamide (Sulamyd)
  • Sulfamethoxazole (Bactrim, Septra)
  • Sulfanilamide
  • Sulfasalazine (Azulfidine)
  • Sulfisoxazole (Gantrisin)
  • Sulfamethoxypyridazine

Cytotoxic / Antibacterial:

  • Nalidixic Acid
  • Para-Aminosalicylic Acid
  • Chloramphenicol
  • Co-Trimoxazole
  • Furazolidone
  • Furmetonol
  • Neoarsphenamine
  • Streptomycin

Nitrofurans:

  • Nitrofurantoin (Furadantin, Macrobid, Macrodantin)
  • Nitrofurazone (Furacin)

Quinolones and Fluoroquinolones:

  • Ciprofloxacin (Cipro)
  • Levofloxacin (Levaquin)
  • Moxifloxacin (Avelox, Vigamox)
  • Norfloxacin (Noroxin)

Cardiovascular Drugs:

  • Captopril
  • Hydralazine
  • Procainamide
  • Quinidine
  • Enalapril

MISCELLANEOUS:

  • Acetylsalicylic Acid (ASA, Mejoral)
  • Ascorbic Acid (Vitamin C)
  • Para-Aminobenzoic Acid (Complex B10)
  • Tonic water
  • Alpha Methyldopa
  • Aminopyrine
  • Antazoline
  • Methylene Blue (used in contrast)
  • Toluidine blue (used in contrast)
  • Bupivacaine (anesthesia)
  • Colchicine
  • Artificial Dyes
  • Diphenhydramine (Anador, Caladryl)
  • Dimercaprol
  • Fava beans
  • Phenylbutazone
  • Phenytoin (Hydantal)
  • Glibenclamide
  • Isoniazid
  • L-Dopa
  • Mestranol
  • Naphthalene
  • Niridazole
  • Piridium
  • Pyrimethamine
  • Sulfacillin
  • Sulfadiazine
  • Sulfaguanidine
  • Sulfamerazine
  • Sulfamethoxypyridazine
  • Trimetropim (Bactrim)
  • Trinitrotoluene
  • Tripelenamine
  • Urato Oxidase
  • Red wine
  • Vitamin K (Kanakion)
  • Acetylphenylhydrazine
  • Beta-Naphthol
  • Chloramphenicol
  • Dimercaprol
  • Glyburide (Diabeta)
  • Henna
  • Menthol
  • Penicillamine
  • Phenazopyridine
  • Phenylhydrazine
  • Rasburicase (Elitek)
  • Tolbutamide (Orinase)

SOURCE:

PEDIATRIC HEMATOLOGY DEPARTMENT OF THE SCHOOL PAULISTA DE MEDICINA. RESEARCHERS DR.SERGIO AUGUSTO PERLAMAGNA (CRM: 99243), DRA ELISA COUTO PERES RIBEIRO (CRM: 125075)

Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371(9606):64–74

Minucci A, Moradkhani K, Hwang MJ, et al. Glucose-6-phosphate dehydrogenase (G6PD) mutations database: review of the ‘old’ and update of the new mutations. Blood Cells Mol Dis. 2012;48(3):154–165.

The Association is affiliated with UNIAMO, Italian Federation for Rare Diseases, which is member of EURORDIS, European Organization for Rare Diseases.

 

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